Protein mechanics probed using simple molecular models
نویسندگان
چکیده
منابع مشابه
Statistical mechanics of simple models of protein folding and design.
It is now believed that the primary equilibrium aspects of simple models of protein folding are understood theoretically. However, current theories often resort to rather heavy mathematics to overcome some technical difficulties inherent in the problem or start from a phenomenological model. To this end, we take a new approach in this pedagogical review of the statistical mechanics of protein f...
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Most reactions in cells are carried out by enzymes [1]. In many instances the rates of enzyme-catalyzed reactions are enhanced by million fold. A significantly large fraction of all known enzymes are proteins which are made from twenty naturally occurring amino acids. The amino acids are linked by peptide bonds to form polypeptide chains. The primary sequence of a protein specifies the linear o...
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A simple molecular mechanics model has been used to investigate optimal spool-like packing conformations of double-stranded DNA molecules in viral capsids with icosahedral symmetry. The model represents an elastic segmented chain by using one pseudoatom for each ten basepairs (roughly one turn of the DNA double helix). Force constants for the various terms in the energy function were chosen to ...
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Doublié, S., Sawaya, M.R., and Ellenberger, T. (1999). Struct. Fold. son and Beese, 2004). The same mispair, on the other Des. 7, R31–R35. hand, is poorly extended by Dpo4: it was shown to form Echols, H., and Goodman, M.F. (1991). Annu. Rev. Biochem. 60, a reverse wobble, which misaligns the 3 -end of the 477–511. primer and therefore precludes nucleophilic attack (TrinHatahet, Z., Zhou, M., R...
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Recent experiments have demonstrated that proteins unfold when two atoms are mechanically pulled apart, and that this process is different to when heated or when a chemical denaturant is added to the solution. Experiments have also shown that the response of proteins to external forces is very diverse, some of them being "hard," and others "soft." Mechanical resistance originates from the prese...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2020
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2020.129613